Evaluation of curative potency andin silicoanalysis of Elaeocarpus ganitrus
Elaeocarpus ganitrus( Syn.Tocopherol sphaericus) belongs to a household of Elaeocarpaceae. It is normally known as Rudraksha. It is a big evergreen wide leaved tree found in tropical and semitropical countries i.e, Asssam and Himalayan parts of India. These species of workss are besides broad spread in the states like Southeast Asia, Japan, Australia, Fiji and Hawaii. The tree grows within a suited temperature scope of 25-30EsC and it starts bearing fruits in 7 old ages. It is an ethnomedicinally of import works that possesses a broad scope of pharmacological belongingss which could be used to handle assorted diseases. The foliages, fruits and bark of the tree contains the active compounds which could be used in the intervention of emphasis, anxiousness, megrim, asthma, skin disease etc. The active compounds present in the works are elaeocapidine, cucurbitacin, ellagic acid, flavonoids, quercetin, rudrakine. The pharmacological activities ofElaeocarpus ganitrusare that it can move as an antioxidant, fungicide, antibacterial, anticancer, antihypertensive, antidiabetic, anti-inflammatory and analgetic.
Therefore, from the literature survey suited extractions methods are used to pull out the active compounds from different parts of the works to analyze the pharmacological belongingss. The -inhibitory potency of each of the active compound will be evaluated against different malignant neoplastic disease marks byin silicoanalysis followed by cistron web building for network/pathway analysis.
Keywords:Elaeocarpus ganitrus, Rudraksha, anticancer, cucurbitacin, ellagic acid.
Elaeocarpusbelongs to a genus of tropical and semitropical trees of the householdElaeocarpus family. There are around 350 species of this tree which is widely distributed in the parts of India, Southeast Asia, Malaysia, Southern China, Japan, Australia, Fiji and Hawaii. Out of all the different species ofElaeocarpus,Elaeocarpus sphaericuscontains some of the medically and pharmacologically of import chemical compounds.Elaeocarpus sphaericusis normally called as Rudraksha. The word Rudraksha was derived from Sanskrit words- ‘rudra’ which means Godhead shibah and ‘Aksha’ agencies eyes.In India rudraksha is cultivated in the countries of gangetic field in foothills of Himalayas.
Elaeocarpus ganitrusis a wide leaved tree, the foliages appear glistening green on the upper side and dull viridity on the dorsal side. It requires a temperature scope of 25-30EsC. It grows up to 50-200 metres tall and the bole of up to 1.22 metres long. The bark of the tree has unsmooth texture and flowers are white. The tree starts bearing fruit after 7 old ages. These flowers turn into a blue coloured fruit and on to the full maturing outputs ruddy coloured seeds or beads. The bead formation and the type of bead formed depend on the environment and location of the rudraksha tree. Rudraksha are categorized based on the figure of ‘mukhis’ it has i.e. , is the figure of faces or clefts present on the surface of the bead. Rudraksha comes from 1 to 38 mukhis but, rudraksha of 1-14 mukhis are normally found. Each mukhi has its ain curative potencies, benefits and powers.
The foliages bark and the fruits of the rudraksha tree possess ethanomedically of import properties.It contains active compounds which can be used to bring around several complaints. There are traditional ayurvedic belongingss of rudraksha every bit good as some of the medicative and scientific values ofElaeocarpus ganitrus.The traditional utilizations ofElaeocarpus ganitrusincludes, rudraksha Acts of the Apostless as a blood purifier, possess antiaging belongingss, improves memory power, remedy external respiration job, epilepsy direction etc. Some of the pharmacological activities possessed byElaeocarpus ganitrusare, it acts as an antioxidant, has antifungal, antibacterial, anxiolytic, anticancer, antihypertensive and antidiabetic belongingss.
Elaeocarpus ganitrusRoxb. ( Syn.E. sphaericus) belongs to the householdElaeocarpus family, is popular for its attractive fruit rocks. Its beads are covered by an outer shell of bluish colour on to the full maturing, hence besides called blueberry beads. It finds a outstanding topographic point in Hindu faith and Ayurveda, the antediluvian Indian system of medical specialty.
Rudraksha is botanically called asElaeocarpus ganitruswhich best grows in tropical and semitropical parts.Elaeocarpus ganitrusis found in India, SouthEast Asia, Australia, hilly parts of Nepal, Indonesia, Java, Sumatra, Hawaii etc. It is a big evergreen wide leaved tree. The tree is about 50-200 metres tall. It has a cylindrical bole with unsmooth textured bark. The morphological presentation shows thatElaeocarpus ganitrusfoliages are reflecting viridity on the upper side with dull leathery on the dorsal side. The flowers are white in colour which bloom in the rainy season. The flowers turn into bluish coloured fruits which on maturing outputs chocolate-brown ruddy colored seeds. The tree grows throughout the twelvemonth with a temperature demand of 25-30EsC. The tree starts bearing fruits after 7 old ages. Fruits appear in June and turn up by August to October. The bead formation and the type of the bead formed depend on the environment and the location of the rudraksha tree. There are different types of rudraksha beads and they are categorized depending on the figure of ‘mukhis’ that is the clefts or the face on the surface of the bead. The ancient Bibles province that there are 1 to 38 mukhis, but rudrakhas of 1 to 14 mukhis are normally found. Five faceted rudraksha or punchmukhi rudraksha bead is most normally found. Each mukhi of rudraksha possess alone therapeutical potencies and benefits ( Joshiet Al, 2014 ) .
The biochemical components ofElaeocarpus ganitrusshows that the rudraksha is constructed of C, H, N and O. Aqueous infusion of foliages contains glucosides, proteins, tannic acids, alkaloids, flavanoids, phytosterols etc. The ethanolic infusion of foliages contains Gallic acid, ellagic acid and quercetin. Two of the alkaloids are isoelaeocarpiline, elaeocarpiline, elaeocarpidine, rudrakine and includes fatty acids like palmitic acid and linolenic acid. ( Singh, 2014 ) .
Rudraksha fruits are thermogenic, ataractic and utile in cough, megrim and other encephalon upsets ( Singh et al, 2010 ) .The flesh or mush of fruit is given in epilepsy and mental unwellness. It is besides reported to exhibit pharmacological activities that include fungicidal, antibacterial, anti-inflammatory, anodynes, ataractic, antidepressant, antiasthmatic, antidiabetic, antihypertensive, anticonvulsant and antineoplastic belongingss.
- To analyze the pharmacological activities ofElaeocarpus ganitrus.
- Docking surveies to analyze the repressive potency of the active compounds against the malignant neoplastic disease receptors.
- Gene web building for network/pathway analysis.
AUTODOCK, CYTOSCAPE/GENEMANIA, NETWORK ANALYST, iGEMDOCK, DISCOVERY STUDIO
PDB, PUBCHEM, CHEMSPIDER, KEGG
- Collection of works stuffs: the foliages, bark and fruit
- Preparation of infusions
- Download the constructions of active compounds and malignant neoplastic disease receptors.
- Docking of the malignant neoplastic disease receptors to the active compounds found in theElaeocarpus ganitrus.
- Gene web building to place the hub node and for network/pathway analysis.
The foliage, fruit and bark infusions ofElaeocarpus ganitrusshowed possible pharmacological activities ofElaeocarpus ganitrus. Based on the moorage surveies few of the receptors with best adhering energy, tantrum in the active site and the figure of hydrogen bonds formed between the malignant neoplastic disease receptors and the active compound were chosen. Then based on the moorage consequences, cistron web building can done for that to happen the hub node and for farther analysis. Gene web building helps to place the hub node for a peculiar disease. It can besides be used to research the topological web belongingss of the cistron and show that cistron network/pathway analysis.
Elaeocarpusspecies have been used successfully used from several centuries in traditional medical specialty and Ayurveda to handle different types of upsets and diseases. More clinical tests should be carried out to back up the curative usage and should be farther tested on the different cell lines to measure its curative potency. It is besides of import to analyze its possible effects when administered in combination with other natural herbs and drugs.
- Joshi S, Gupta P, Kumar N, Rai N, Gautam P, and Thapliyal A ( 2012 ) .A comprehensive study on curative potency of Elaeocarpus ganitrus Roxb. ( Rudraksha ) . Environment Conservation Journal, 13 ( 3 ) 147-150.
- Joshi SC and Jain PK ( 2014 ) . A reappraisal on ethnomedicinal and traditional utilizations of Elaeocarpus ganitrus roxb. ( Rudraksha ) .Int J Pharm Bio Sci, 5 ( 1 ) :495 – 511.
- Singh R ( 2014 ) . Pharmacognostical, Physicochemical and HPTLC surveies of Elaeocarpus ganitrus Leaves. International Journal Of Drug Discovery And Herbal Research, 4 ( 1 ) :722-732.
- Singh B, Chopra A, Ishar MPS, Sharma A and Raj T. Pharmacognostic and Antifungal Investigations of Elaeocarpus ganitrus ( Rudrakasha ) .
- Sun J, Jia P, Fanous AH, new wave lair Oord E, Chen X ( 2010 ) . Schizophrenia Gene Networks and Pathways and Their Applications for Novel Candidate Gene Selection. PLOS ONE 5 ( 6 ) : 11-35.